1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
lomefloxacin
CAS: 98079-51-7
Molecular Formula: C17H19F2N3O3
1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid - Names and Identifiers
| Name | lomefloxacin |
| Synonyms | LFLX LEMOFLOXACIN LOMEFLOXACIN lomefloxacin LoMenfloxacin LOMEFLOXACIN BASE 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolin 1-Ethyl-6,8-difluoro-7-(3-methylpiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-2,3-dihydroquinoline-3-carboxylic acid 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid |
| CAS | 98079-51-7 |
| EINECS | 619-317-6 |
| InChI | InChI=1/C17H21F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,9,11,20H,3-5,7-8H2,1-2H3,(H,24,25) |
1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid - Physico-chemical Properties
| Molecular Formula | C17H19F2N3O3 |
| Molar Mass | 351.35 |
| Density | 1.342±0.06 g/cm3(Predicted) |
| Melting Point | 239-240 C |
| Boling Point | 542.7±50.0 °C(Predicted) |
| Flash Point | 301.3°C |
| Vapor Presure | 4.87E-14mmHg at 25°C |
| pKa | -0.25±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.547 |
| Physical and Chemical Properties | Colorless needle crystals were obtained from ethanol with a melting point of 239~240.5 ℃. Acute toxicity 50 mice (mg/kg):245.6 intravenous injection;>4000 oral administration. Lomefloxacin hydrochloride (Lomeflocacin Hydrochoride):C17H19F2N3O3?HCl. [98079-52-8]. Colorless needle crystals are obtained from water with a melting point of 290~300 ℃ (decomposition). |
| Use | Mainly used for the treatment of a variety of gram-positive bacteria and negative bacteria caused by acute and chronic infectious diseases |
1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | VB1997500 |
| HS Code | 29419000 |
| Toxicity | LD50 in mice (mg/kg): 245.6 i.v.; >4000 orally (Itoh) |
1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid - Nature
Open Data Verified Data
colorless needle-like crystals were obtained from ethanol, with a melting point of 239-240.5 °c. UV maximum absorption (0. 15molll acetate buffer. pH = 5): 226,288,320nm (am× 10-3 15.5.36.7,13.5);UV maximum absorption (0. 05m phosphate buffer, pH = 7):282, 326nm (am× 10 -331.5. 13.3).
Last Update：2024-01-02 23:10:35
1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid - Preparation Method
Open Data Verified Data
with 2,3,4,5 A tetrafluorobenzoic acid as raw material, by thionyl chloride chloride for acid chloride, and ethoxymalonic acid Diethyl ester condensation, decarboxylation to produce tetrafluorobenzoyl ethyl acetate. Under the action of acetic anhydride and triethyl orthoformate condensation, the obtained material and ethylamine reaction, in the role of sodium hydride cyclization of quinoline ring derivatives, ester hydrolysis into carboxyl group, and then 2 methyl piperazine reaction, lomefloxacin was obtained.
Last Update：2022-01-01 09:08:54
1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid - Use
Open Data Verified Data
developed by Japan Beilu Pharmaceutical Co., Ltd., and jointly developed by Beilu and yanouyi Co., Ltd., and transferred to Japan Qianshou Co., Ltd. and Searl Co., Ltd., USA. It was first launched in Argentina in 1989 and later in numerous other countries. For long-acting oral antibacterial quinolones. The antibacterial effect is exerted by inhibiting bacterial DNA gyrase to stop the growth of bacteria. Broad antibacterial spectrum, high efficiency, safety, metabolic stability, good tolerance. Because there is no cross effect with theophylline, there is no contraindication for asthma patients, so it is especially suitable for the elderly. Can be used for respiratory tract infection, sepsis, enteritis, urinary tract infection, gynecological disease infection, eye and oral infection, can also be used to prevent infection after surgery.
Last Update：2022-01-01 09:08:54
1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid - Safety
Open Data Verified Data
mouse LDso (mg/kg):245.6 intravenously;>4000 orally.
Last Update：2022-01-01 09:08:55
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CAS: 98079-51-7
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